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Journal of Pharmacology And Experimental Therapeutics, Vol. 108, Issue 3, 340-348, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

A COMPARISON OF THE PHARMACOLOGICAL ACTIONS OF PHENOTHIAZINE DERIVATIVES USED IN THE TREATMENT OF PARKINSONISM

Duncan E. Hutcheon 1

1 Department of Pharmacology, Oxford, and the University of Saskatchewan, Saskatoon

The three derivatives of aminoethylphenothiazine, Diparcol, Phenergan and Parsidol, caused the following pharmacological effects:

(1) local anesthesia when injected intradermally in guinea pigs,

(2) inhibition of the acetylcholine induced contractions of the isolated guinea pig ileum,

(3) inhibition of salivary secretion induced by the infusion of carbachol in anesthetized dogs,

(4) lengthening of the refractory period of the isolated rabbit auricles as measured by the decrease in the maximal rate of stimulation.

Quantitative results were obtained and in all tests Parsidol was found to be the most active of the three phenothiazine derivatives tested.

Finally, it was shown that, in cats under chloralose, Diparcol did not inhibit gastric acid secretion produced by histamine.

Submitted on February 3, 1953






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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.