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Journal of Pharmacology And Experimental Therapeutics, Vol. 108, Issue 3, 336-339, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

ANALGESICS

I. Effects of Analgesic Combinations on Reaction Time in Rats

Carl C. Smith 1 and E. G. Lehman 2

1 Christ Hospital Institute of Medical Research, Cincinnati 19, Ohio
2 Merck Institute for Therapeutic Research, Rahway, New Jersey

1. Combined administration of methadone and alpha-methadol to rats produced a prolonged increase in reaction time which was equivalent approximately to the sum of the effects obtained when the two compounds were given separately.

2. The analgesic activity of isomethadone was partially blocked by a large dose of the inactive derivative, alpha-isomethadol.

3. Additive analgesic effects were obtained with combinations of methadone and alpha-acetylmethadol and alpha-acetylmethadol levorotatory.

4. Combined administration of methadone and morphine or methadone and isomethadone gave no greater increases in reaction time than those obtained when the more active component of the mixture was given alone.

Submitted on February 2, 1953






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