INHIBITION OF ULCER FORMATION IN THE SHAY RAT AND REDUCTION OF GASTRIC ACIDITY IN DOGS BY ANTRENYL (OXYPHENONIUM) (BA-5473) DIETHYL (2-HYDROXYETHYL) METHYLAMMONIUM BROMIDE -PHENYL-CYCLOHEXANEGLYCOLATE, AN ANTICHOLINERGIC AGENT

¹ Research Department, Ciba Pharmaceutical Products, Inc., Summit, New Jersey

1. The Shay rat procedure has proved to be an effective technique for the study of drugs possessing possible anti-ulcer activities.

2. Compared on a molar-equivalent basis, Antrenyl possesses greater anti-ulcer properties than either atropine or methantheline. The anti-ulcer property of Antrenyl in the Shay rat appears to depend not on a ganglionic blocking mechanism, but rather on its anticholinergic properties. Its greater potency in this respect may in part be related to its longer duration of action.

3. Antrenyl effectively suppresses the gastric secretion induced by a meat meal in the Pavlov dog, and that evoked by insulin in gastric fistula dogs.

4. In the experiments reported herein, Antrenyl was found to be approximately as effective as atropine and more effective than methantheline bromide in the suppression of canine gastric secretion from Pavlov pouches and gastric fistulas.

5. In the experimental results obtained to date, Antrenyl has not consistently suppressed the gastric secretion evoked by the subcutaneous administration of histamine.