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Journal of Pharmacology And Experimental Therapeutics, Vol. 108, Issue 2, 217-223, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

A METHOD FOR THE EVALUATION OF ANTITUSSIVE AGENTS IN THE UNANESTHETIZED DOG

P. L. Stefko 1 and W. M. Benson 1

1 Department of Pharmacology, Hoffmann-La Roche Inc., Nutley 10, New Jersey

1. A method of inducing reproducible cough responses in the unanesthetized dog is described. The method is based upon the stimulation of a localized area of the tracheal submucosa by means of embedded electrodes.

2. Employing this technique, codeine phosphate was found to possess greater antitussive activity than morphine sulfate. The administration of saline was ineffectual in inhibiting coughs.

Submitted on January 16, 1953






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