JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Weidmann, H.
Right arrow Articles by Petersen, P. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Weidmann, H.
Right arrow Articles by Petersen, P. V.
Journal of Pharmacology And Experimental Therapeutics, Vol. 108, Issue 2, 201-216, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

A NEW GROUP OF POTENT SEDATIVES

H. Weidmann 1 and P. V. Petersen 1

1 Research Laboratories, H. Lundbeck and Company, A/S, Kopenhagen

A series of 37 compounds, in the majority closely related to the antihistamine Benadryl, has been studied for sedative, convulsant, spasmolytic, and toxic properties in mice. A correlation of structure with pharmacologic activity has been attempted. Qualitatively, as far as the present investigations are concerned, these compounds resemble Benadryl in pharmacological action. Quantitatively with regard to sedation, some of these preparations, especially the higher alkylated alkylmercapto-benzohydryl ethers and thioethers were found to be two to four times as potent as Phenergan, the median sedative dose of which was determitied as 23.4 mgm./kgm. intraperitoneally.

The technical assistance of Miss A. Grove and Miss E. Moeller is gratefully acknowledged.

Submitted on January 15, 1953




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
I. Inoue, K. Yanai, D. Kitamura, I. Taniuchi, T. Kobayashi, K. Niimura, T. Watanabe, and T. Watanabe
Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors
PNAS, November 12, 1996; 93(23): 13316 - 13320.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.