JPET Introducing ALZET?ew Model 2006 Pump

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Journal of Pharmacology And Experimental Therapeutics, Vol. 108, Issue 1, 61-68, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

IN VIVO INHIBITION OF BARIUM STIMULATED INTESTINAL MOTILITY BY ATROPINE

H. Necheles 1, W. Scruggs 1, S. Kraft 1, and W. H. Olson 1

1 Department of Gastro-Intestinal Research, Medical Research Institute of Michael Reese Hospital, Chicago, Illinois

1. Atropine sulfate had the following effects on intestinal motility stimulated by barium: a) no effect on intestinal strips in vitro; b) inhibitory effect in majority of tests on anesthetized dogs.

2. It is concluded that studies on the intestinal strip in vitro are not a reliable indicator for the effect of antispasmodic drugs in the whole animal.

3. The anesthetized dog offers certain advantages for the study of antispasmodic drugs on the gastro-intestinal tract. The method may show the following: a) the most effective route of administration of an antispasmodic; b) which organ responds most and which organ least; c) the effect of antispasmodics on distant organs when the drug is instilled into specific segments of the intestinal tract.

Submitted on December 12, 1952






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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.