CORONARY DILATOR ACTION. II. CARDIOVASCULAR STUDIES ON TWO ACTIVE COMPOUNDS, 2-DIETHYLAMINOETHYL DICYCLOHEXYLCARBAMATE HYDROCHLORIDE AND 2-DIETHYLAMINOETHYL TRIPHENYLMETHANE-2-CARBOXYLATE HYDROCHLORIDE

¹ Division of Biological Research, G. D. Searle & Co., Chicago 80, Illinois

The cardiovascular actions of two synthetic coronary dilator compounds, SC-2401, 2-diethylaminoethyl dicyclohexylcarbamate hydrochloride, and SC-2027, 2-diethylaminoethyl triphenylmethane-2-carboxylate hydrochloride, were studied. Intra-arterial injection of 6 to 80 microgm./kgm. of either compound into the coronary, femoral or superior mesenteric vascular bed resulted in an augmented rate of blood flow without influencing blood pressure, cardiac output or cardiac work.

Intravenous injection of 1 to 4 mgm./kgm. of either compound produced an increase in the blood flow in the coronary and femoral vascular areas. This was preceded by a transient decline in the flow rates. Stroke volume and cardiac output were increased during the period of reduced flow; blood pressure and total peripheral resistance were reduced. During the period of increased flow, coronary resistance was reduced. SC-2027 on intravenous injection caused marked alterations in the electrocardiogram; no such changes were observed with SC-2401.

The increase in the blood flow rate in the coronary or femoral vascular beds appeared to be the result of vasodilatation.