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Journal of Pharmacology And Experimental Therapeutics, Vol. 108, Issue 1, 18-25, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

THE RELIABILITY OF GRAPHIC ESTIMATES OF RELATIVE POTENCY FROM DOSE-PER CENT EFFECT CURVES

John T. Litchfield Jr. 1 and Frank Wilcoxon 1

1 Stamford Research Laboratories and Lederle Laboratories Division, American Cyanamid Company, Stamford, Connecticut, and Pearl River, New York

1. Critical examination of a recent study claiming to evaluate the Litchfield-Wilcoxon procedure for rapid graphic solution of bioassays based on dose-per cent effect curves revealed the following:

(a) the procedure had been modified in a manner which increased the error by 5-fold over the unmodified method.

(b) the study was based entirely on the use of this modified procedure; therefore, the conclusions do not apply to the Litchfield-Wilcoxon procedure.

2. When the same bioassay problem used in the above-mentioned study was solved by 21 subjects having no previous experience with biostatistics, the Litchfield-Wilcoxon procedure gave estimates which were in satisfactory agreement with the value obtained by probit analysis.

Submitted on December 1, 1952






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