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Journal of Pharmacology And Experimental Therapeutics, Vol. 107, Issue 4, 524-530, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

ACTIONS AND ADDICTION LIABILITIES OF DROMORAN DERIVATIVES IN MAN

Harris Isbell 1 and H. F. Fraser 1

1 National Institute of Mental Health, Addiction Research Center, Public Health Service Hospital, Lexington, Kentucky

The levorotatory isomers of Dromoran and methyl Dromoran account for all the miotic and respiratory depressant effects of the racemates of these compounds. The dextrorotatory isomers have no significant effects on pupillary size or respiratory minute volume.

The effects of l-methyl Dromoran appear sooner and are more intense after oral administration, as compared with subcutaneous administration. l-Dromoran is less effective when administered orally.

l-Dromoran and l-methyl Dromoran possess addiction liability of a high order. The addicting potentialities of l-methyl Dromoran exceed those of codeine.

d-Dromoran and d-methyl Dromoran are devoid of addiction liability.

Submitted on November 24, 1952




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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.