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Journal of Pharmacology And Experimental Therapeutics, Vol. 107, Issue 3, 379-384, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

ANTI-EJACULATORY EFFECT OF SYMPATHOLYTIC, GANGLIOLYTIC AND SPASMOLYTIC DRUGS

S. Loewe 1 and Susanne L. Puttuck 1

1 Department of Pharmacology, University of Utah College of Medicine, Salt Lake City, Utah

1. Ejaculation in the mouse, induced by drugs, was employed as a test function for the influence of a number of autonomic and spasmolytic drugs upon the ejaculatory process.

2. The results obtained with this method are compatible with the concept that the major efferent pathways of the ejaculatory reflex are sympathetic and the effector organs are adrenergic.

3. Dibenamine and four other haloalkylamine derivatives as well as the two sympatholytic imidazolines tested, Pniscoline and Regitine, were capable of abolishing the ejaculatory response roughly in proportion to their sympatholytic potency.

4. Two gangliolytics, C5 and C6, were also effective in doses comparable to those blocking sympathetic ganglia; markedly higher doses of tetraethylammonium appear to be required for comparable effects.

5. The two spasmolytic drugs tested, papavenine and Trasentine, also exhibited anti-ejaculatory effectiveness, but in doses higher than those depressing other smooth muscles.

Submitted on October 24, 1952




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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.