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Journal of Pharmacology And Experimental Therapeutics, Vol. 107, Issue 3, 344-355, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

SITE OF ACTION OF 2,2-DIETHYL 1,3-PROPANEDIOL (PRENDEROL) ON THE CENTRAL NERVOUS SYSTEM

W. H. Funderburk 1 and K. R. Unna 2

1 Traverse City State Hospital, Traverse City, Michigan
2 Department of Pharmacology, University of Illinois College of Medicine, Chicago 12, Illinois

The effects of Prenderol have been studied at various levels of the cerebrospinal axis, alld compared with the effects of mephenesin.

1. The drug had a depressant action on spinal interneurons similar to that of mephenesin.

2. Its potency was approximately one-third of that of mephenesin and its duration of action was shorter.

3. The action of mephenesin on the EEG suggested depression of interneurons in the brain stem activating system and in thalamo-cortical pathways. In contrast Prenderol showed stimulating effects above the spinal level.

Submitted on October 23, 1952






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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.