COMPARATIVE PHYSIOLOGICAL ACTIONS OF SOME ALKANE-DIAMINES

¹ Department of Pharmacology and Experimental Therapeutics, University of California Medical School, San Francisco
² Laboratories of Gordon A. Alles, Ph.D., Pasadena

1. Decane-1,10-diamine and a number of closely related alkane-diamines were studied and compared to histamine. Doses 100 to 1000 times greater on a molal basis were required to produce a comparable intensity of depressor effect in dogs and guinea pigs.

2. Unlike histamine, the most active of these diamines, decane-1,10-diamine, does not cause any pressor effect in the rabbit.

3. On a molal ratio basis the depressor activities of decane-1,10-diamine are not as effectively blocked as those of histamine by anti-histamine agents. Blocking effectiveness towards decane-1,10-diamine as compared with that towards histamine is not the same for different antihistamine compounds.

4. No changes of histamine-like activity in the plasma of guinea pigs could be demonstrated following closes of decane-1,10-diamine which produce marked depressor responses.

5. On isolated ileum the alkane-diamines caused slight relaxations with minimally active bath concentrations, and contractions with higher concentrations. They are much less active than histamine in producing a contraction of the ileum.

6. Intradermal injections of the most active alkane-diamines into the skin in man cause a flare and wheal response similar to that of histamine, but they are only 1/100 as active.

7. Acute lethal toxicity of the most active alkane-diamines is about the same for intraperitoneal injection into mice, rats or guinea pigs. Gastric lesions and erosions were noted in guinea pigs receiving lethal doses. Deeane-1,10-diamine, which showed such effects with lethal doses, is not an effective stimulant of gastric acid secretion.