A PRELIMINARY STUDY OF THE ANTHELMINTIC ACTIVITY OF CYANINE DYE #715 IN DOGS

¹ Department of Pharmacology, School of Medicine, Western Reserve University, Cleveland, Ohio

Various cyanine dyes, particularly one termed #715, given orally, exerted appreciable vermicidal activity in the chemotherapy of ascariasis, trichuriasis, and ancylostomiasis in the dog, but were of no value in the treatment of canine tapeworm infestations.

The chief toxic signs associated with oral therapy with #715 were: a) anorexia and occasional vomiting during the first six hours after ingestion of the drug, and mild diarrhea of a transient nature beginning twelve to sixteen hours after treatment; b) a mild renal tubular change of a reversible nature when the drug was given in the therapeutic dosage schedules described. With frequent administration of large doses, these renal changes were more pronounced.