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Journal of Pharmacology And Experimental Therapeutics, Vol. 107, Issue 3, 259-265, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

ISOLATION OF AN EPOXIDE METABOLITE FROM FAT TISSUES OF DOGS FED HEPTACHLOR

Bernard Davidow 1 and Jack L. Radomski 1

1 Federal Security Agency, Food and Drug Administration, Washington 25, D. C.

1. A metabolically altered derivative is stored in the fat of dogs fed heptachlor.

2. Countercurrent distribution and adsorption chromatography were used to isolate 76 mgm. of metabolite from 350 gm. of fat.

3. The metabolite has been identified as the epoxide of heptachlor.

4. The existence of a new pathway of biological oxidation, namely, epoxidation, has been demonstrated.

Submitted on September 10, 1952




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B. Davidow, J. L. Radomski, and R. Ely
Excretion of Heptachlor Epoxide in Milk of a Dairy Cow Fed Heptachlor
Science, October 2, 1953; 118(3066): 383 - 384.
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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.