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Journal of Pharmacology And Experimental Therapeutics, Vol. 107, Issue 2, 241-249, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

THE ABSORPTION AND EXCRETION OF DROMORAN

A. L. Fisher 1 and J. P. Long 2

1 Department of Pharmacology, College of Medicine, State University of Iowa, Iowa City, Iowa
2 Graduate College, State University of Iowa

1. A modification of the methyl orange technique for basic amines has been developed for the determination of Dromoran in plasma, urine and gastro-intestinal tract contents.

2. Urinary excretion data indicate a close similarity between non-tolerant and tolerant dogs.

3. The excretions of the l- and d-isomers and of a mixture of d- and l-isomers were found to be similar to the excretion of racemic Dromoran hydrobromide.

4. Dromoran, following intravenous infusion, disappeared very rapidly from the plasma.

5. Dromoran is rapidly absorbed orally when administered to fasted rats.

6. Dromoran is partially excreted as the glucuronide and possibly in some other conjugated form.

Submitted on October 16, 1952






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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.