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Journal of Pharmacology And Experimental Therapeutics, Vol. 107, Issue 2, 188-196, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

BINDING OF DIHYDRO-beta-ERYTHROIDINE BY A CONSTITUENT OF BLOOD PLASMA

L. B. Kirschner 1 and W. E. Stone 1

1 Department of Physiology, University of Wisconsin Medical School, Madison, Wisconsin

An analytical method for curariform agents has been described. The assay is based on the inhibition of the acetyleholine-induced response of the frog rectus abdominis muscle.

Some characteristics of dihydro-beta-erythroidine and d-tubocurarine are described. Both are fairly stable in acid solution and to heat. d-Tubocurarine is also stable in alkaline solution while dihyro-beta-erythroidine is completely destroyed by alkali.

Dihydro-beta-erythroidine hydrobromide, whether injected intravenously or added to blood in vitro, forms a pharmacologically inactive complex with an unidentified constituent of the plasma. The complex is soluble in alcohol, and the curariform activity is restored by heating in acid solution. A small percentage of the injected drug remains in the free form, an apparent equilibrium being established. A "buffering" effect is thus provided which may aid in the achievement of adequate curarization with minimal side effects.

Submitted on October 2, 1952






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