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Journal of Pharmacology And Experimental Therapeutics, Vol. 107, Issue 2, 165-171, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF FREQUENCY OF STIMULATION ON THE PARALYZING DOSE OF NEUROMUSCULAR BLOCKING AGENTS

James B. Preston 1 and E. F. Van Maanen 2

1 Department of Pharmacology, College of Medicine, University of Cincinnati, Cincinnati, Ohio
2 Department of Pharmacology, University of Illinois College of Medicine, Chicago 12, Illinois

The effect of frequency of stimulation on the paralyzing dose of Flaxedil, d-tubocurarine, decamethonium, neostigmine, and Tensilon was studied in the sciatic-gastrocnemius preparation of anesthetized rats.

1. For the frequencies tested (0.067 to 5.0 stimuli per second) increase in frequency of stimulation results in a decrease of the PD50 for all five agents.

2. The slopes of the dose-response curves do not differ significantly at the different frequencies of stimulation or among the five compounds.

3. Increasing the frequency of stimulation shortens the interval from injection to the time of peak effect.

4. The average rates of recovery of twitch height in per cent per minute are: Flaxedil 8.5, d-tuhocurarine 11.6, decamethonium 3.8, neostigmine 57.8, and Tensilon 53.2. They are not affected by frequency of stimulation in the range tested.

Submitted on September 23, 1952






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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.