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Journal of Pharmacology And Experimental Therapeutics, Vol. 107, Issue 2, 160-164, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF OVARIAN EXTRACTS UPON ACTIVITY OF THE GUINEA PIG UTERUS IN SITU

Lloyd C. Felton 1, Harold H. Bryant 2, and Edward H. Frieden 3

1 Biological Laboratories of Hynson, Westcott, and Dunning, Inc., Baltimore, Md.
2 The Biological Laboratories , Harvard University, Cambridge, Mass.
3 Tufts College Medical School, Boston, Mass.

Studies of the chemical properties of a uterine relaxing factor (URF), obtained from aqueous extracts of sows' ovaries indicate that the active agent is non-dialyzable, stable to heat, and sensitive to the action of proteolytic enzymes and a variety of reducing agents. It is concluded that URF is a protein or polypeptide. URF activity is also displayed by both crude and purified relaxin preparations, and comparison of the occurrence of URF and relaxin in various tissues suggests a close relationship between the two substances.

The possible relationship of protein-like hormones of the reproductive tract to changes in uterine motility have been discussed.

Submitted on September 23, 1952




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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.