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Journal of Pharmacology And Experimental Therapeutics, Vol. 107, Issue 1, 37-53, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

THE HISTOCHEMICAL LOCALIZATION OF ACETYL-CHOLINESTERASE IN NERVOUS TISSUE

Herbert A. Ravin 1, Sumner I. Zacks 1, and Arnold M. Seligman 1

1 Yamins Laboratory for Surgical Research, Beth Israel Hospital, Boston and Department of Surgery, Harvard Medical School

A new method is described for the histochemical localization of acetylcholinesterase in fresh frozen sections of nervous tissue, based upon the acetyl-esterase function of this enzyme. Evidence by means of specific inhibitors is given that staining in nervous tissue is due mainly to acetylcholinesterase activity. Enzymatic activity was demonstrated in the cytoplasm and cell membranes of neurocytes, in the neuropile and in myoneural junctions. Cell nuclei were free of enzymatic activity. Illustrations are given.

Submitted on August 15, 1952




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Simple Method for Histochemical Detection of Esterase Activity
Science, September 23, 1955; 122(3169): 556 - 556.
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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.