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Journal of Pharmacology And Experimental Therapeutics, Vol. 107, Issue 1, 1-11, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

THE PHARMACOLOGY OF NO. 48-80, A LONG-ACTING VASODEPHESSOR DRUG

Peter B. Dews 1, A. Lloyd Wnuck 1, R. V. Fanelli 1, Amos E. Light 1, John A. Tornaben 1, Stata Norton 1, C. H. Ellis 1, and Edwin J. de Beer 1

1 The Wellcome Research Laboratories, Tuckahoe 7, New York

1. Some pharmacological properties of No. 48-80, a highly potent depressor substance obtained by the condensation of N-methylhomoanisylamine with formaldehyde, have been described.

2. The effects of sub-lethal doses resemble those of histamine in many respects although the drug does not possess histamine-like properties itself.

3. No. 48-80 also exhibits certain properties not shown by injected histamine.

Submitted on July 15, 1952






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