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Journal of Pharmacology And Experimental Therapeutics, Vol. 106, Issue 4, 440-443, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT ON BLOOD PRESSURE AND TOXICITY OF 1-(3-FLUOROPHENYL)-2-AMINOETHANOL AND RELATED COMPOUNDS

A. M. Lands 1

1 Pharmacology Section, Sterling-Winthrop Research Institute, Rensselaer, New York

The results of this investigation have shown 1-(3-fluorophenyl)-2-isopropyl-aminoethanol and the N-methyl analog to be weak pressor agents. The primary amine is most pressor and this activity is diminished by alkyl substitution of the amine. When the amino alkyl group is larger than methyl, pressor action is lost and depressor effects are obtained. Depressor action is greatest with the N-isopropyl analog.

The toxicity of 1-(3-fluorophenyl)-2-aminoethanol and the N-alkyl analogs is comparatively low. The most toxic compounds are the depressor amines wherein the N-alkyl group is propyl or butyl.

Submitted on August 25, 1952






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.