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Journal of Pharmacology And Experimental Therapeutics, Vol. 106, Issue 4, 433-439, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

A STUDY OF THE METABOLISM OF Cl4 SALICYLAMIDE IN THE HUMAN

H. George Mandel 1, Paul K. Smith 1, and Victor W. Rodwell 2

1 Department of Pharmacology, The George Washington University School of Medicine, Washington 5, D. C.
2 Department of Physiological Chemistry, The University of Wisconsin, Madison, Wisconsin

Salicylamide-C14 has been prepared in this laboratory from C14 salicylic acid.

The major urinary metabolite after the oral administration of 300 mgm. of the drug to cancer patients was identified as the ethereal glucuronide of salicylamide. A small and extremely variable amount of the original drug also was recovered in the urine. No other metabolite could be detected.

No metabolite of salicylic acid was detected, indicating that the substance was not converted to salicylic acid and that the pharmacological action could not be due to the latter substance.

Submitted on August 15, 1952






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.