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Journal of Pharmacology And Experimental Therapeutics, Vol. 106, Issue 4, 429-432, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF ACTH, CORTISONE AND ADRENAL CORTICAL EXTRACT IN EXPERIMENTAL TRAUMATIC SHOCK

Donn L. Smith 1 and Fred E. D'Amour 2

1 Department of Pharmacology, University of Colorado School of Medicine
2 Biological Research Laboratories, University of Denver

The effects of ACTH, cortisone and ACE in experimental traumatic shock were determined using the albino rat as the test animal.

ACTH extended the mean survival time 53 per cent and 55 per cent over control values when administered intravenously and intramuscularly, respectively.

Cortisone increased the mean survival time by 39 per cent with oral administration and 41 per cent when given subcutaneously.

Intravenous infusion of ACE resulted in an 18 per cent prolongation of average survival time.

Submitted on August 11, 1952






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.