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Journal of Pharmacology And Experimental Therapeutics, Vol. 106, Issue 3, 364-369, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE ROLE OF THE LIVER IN THE METABOLIC DISPOSITION OF MEPHOBARBITAL

Thomas C. Butler 1, Darien Mahaffee 1, and Collins Mahaffee 1

1 Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina

By measurement of concentrations of the drugs in plasma, a study has been made of the effect of partial hepatectomy on the metabolic disposition of mephobarbital and phenobarbital in the rat.

Partial hepatectomy has such a large effect on the rate of disappearance of mephobarbital and on the rate of production of phenobarbital from mephobarbital as to suggest that the liver is the principal, if not the only, site of the demethylation of mephobarbital.

Mephobarbital is not as completely converted to phenobarbital in the rat as in the dog.

Submitted on August 20, 1952




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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.