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Journal of Pharmacology And Experimental Therapeutics, Vol. 106, Issue 3, 314-318, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

COMPARISON OF 11-HYDROXY CARDIAC STEROIDS WITH COMPOUND F AND CORTISONE

K. K. Chen 1, Robert C. Anderson 1, and Charles L. Rose 1

1 Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

A group of seven 11-hydroxy cardiac steroids—ouabain, ouabagenin, sarmentocymarin, sarmentogenin, sarmentogenin-l-oleandroside, gamabufagin, and gama-bufotoxin—have been tested for eosinopenia in adrenalectomized Jax C57 Brown mice, and for liver glycogen deposition in adrenalectomized albino mice. They are all found inactive. Compound F and cortisone in smaller doses are effective by both tests.

Submitted on July 15, 1952






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.