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Journal of Pharmacology And Experimental Therapeutics, Vol. 106, Issue 3, 277-285, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE DETERMINATION AND DISTRIBUTION OF TRIMETHADIONE (TRIDIONE) IN ANIMAL TISSUES

J. D. Taylor 1 and E. L. Bertcher 1

1 Department of Pharmacology, Abbott Laboratories, North Chicago, Illinois

A manometric method for the determination of 0.25-1.25 mgm. of Tridione in animal tissues was described.

Doses of 1 gm./kgm. Tridione were absorbed from the penitoneal cavity of the mouse and rabbit with great rapidity. After 15 minutes, the drug was found in blood, brain, muscle, kidney, and liver. The concentration of Tridione declined rapidly in the blood and brain, but less so in the kidney. The concentration of drug was maintained in muscle for 6 hours, then declined. Liver concentrated Tridione slightly reaching a maximum at 2 hours after which the concentration declined. Tridione was present in the liver 12 hours after injection.

In the rabbit no significant difference in the concentration of Tridione was noted in the cortex, white matter, and cerebellum 30 minutes after the intra-penitoneal injection of 1 gm./kgm. of the drug.

Rat tissue slices when incubated 5 hours with Tridione destroyed the drug in the following order of decreasing effectiveness: intestinal mucosa > kidney > liver = muscle > brain.

Submitted on July 7, 1952






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.