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Journal of Pharmacology And Experimental Therapeutics, Vol. 106, Issue 3, 271-276, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

TECHNIQUE FOR DETECTING THE PHARMACODYNAMICALLY INDUCED ALARM REACTION USING THE EOSINOPENIC RESPONSE OF INTACT RATS

Arthur E. Heming 1, Mary F. Sax 1, and Dorsey E. Holtkamp 1

1 Research and Development Division, Smith, Kline, and French Laboratories, Philadelphia, Pa.

The appropriate selection of commercially obtained, adult, intact, male rats, has provided a means of screening compounds for their pharmacodynamic ability to evoke the alarm reaction. The selection of these rats was based on the following criteria: 1) an initial blood eosinophil count of more than 62 eosinophils per c.mm. blood; 2) an eosinopenic response of less than 15 per cent to an intraperitoneal injection of glucose solution; and 3) an eosinopenic response of greater than 25 per cent to an intraperitoneal injection of epinephrine.

Submitted on June 23, 1952






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.