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Journal of Pharmacology And Experimental Therapeutics, Vol. 106, Issue 2, 200-207, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE FATE OF BENZAZOLINE (PRISCOLINE) IN DOG AND MAN AND A METHOD FOR ITS ESTIMATION IN BIOLOGICAL MATERIAL

Bernard B. Brodie 1, Lewis Aronow 1, and Julius Axelrod 1

1 Section on Chemical Pharmacology, National Heart Institute, National Institutes of Health, Public Health Service, Federal Security Agency, Bethesda, Maryland

1. A method is described for the estimation of Priscoline in biological fluids and tissues.

2. Priscoline administered to man and dog has a biologic half life of about two hours and is excreted in urine essentially unchanged.

3. The renal elimination of Priscoline is brought about by a tubular secretory transport mechanism in addition to glomerular filtration.

4. In contrast to Dibenamine, Priscoline is not localized in adipose tissues.

5. In the dog, reversal of the pressor response to a test dose of epinephrine (2.5 microgm. per kgm.) occurs at plasma levels of Priscoline in the approximate range of 2 mgm. per liter and partial blocking at levels in the approximate range of 0.3 mgm. to 2 mgm. per liter.

Submitted on June 7, 1952




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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.