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Journal of Pharmacology And Experimental Therapeutics, Vol. 106, Issue 1, 29-36, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF NITROGEN MUSTARD IN ALLOXAN DIABETES

Frank M. Sturtevant Jr. 1, Francis J. Saunders 1, Lyle D. Calvin 1, and D. M. Green 1

1 Division of Biological Research, G. D. Searle & Co., Chicago 80, Ill.

The effects of nitrogen and sulfur mustards on glycosuria and glycemia were studied in diabetic rats, dogs, and humans. Response in diabetic rats treated intravenously with methyl bis(beta-chlorethyl)amine was measured by decrease in glycosuria, adjusted for the pretreatment level. This response was highly correlated with dosage. The regression on dosage was comparable to similar curves for insulins. The mechanism of action of nitrogen mustards did not appear to involve toxicity or stress. The results were explicable on the basis of a quantitative anorexigenic action, peculiar to a few members of the mustard group.

Submitted on April 10, 1952






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.