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Journal of Pharmacology And Experimental Therapeutics, Vol. 105, Issue 4, 443-449, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF PROGESTERONE AND SOME RELATED STEROIDS ON THE CONTRACTION OF ISOLATED MYOCARDIUM

Bernard Rubin 1 and William T. Salter 2

1 Squibb Institute for Medical Research, New Brunswick, New Jersey
2 Laboratories of Pharmacology and Toxicology, Yale University School of Medicine, New Haven, Connecticut

Three types of cardiac preparation, i.e., isolated papillary muscle of the cat, Langendorff guinea pig heart and isolated frog heart, were subjected to the action of progesterone in synthetic media at concentrations up to 400 microgm./100 ml. Diluted serum with progesterone was employed similarly with the cat papillary muscle.

In the synthetic media when the concentration of progesterone reached 100 microgm./100 ml. (or higher), a negative inotropic action was observed, accompanied or followed by a negative chronotropic action. When progesterone was added to mammalian serum, the negative inotropic effect was ameliorated to about one-fourth of its magnitude in the synthetic media.

No other common steroid among the several tested elicited this effect in concentrations which have been reported to occur normally in mammals.

Submitted on April 26, 1952






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.