JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brodie, B. B.
Right arrow Articles by Mark, L. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brodie, B. B.
Right arrow Articles by Mark, L. C.
Journal of Pharmacology And Experimental Therapeutics, Vol. 105, Issue 4, 421-426, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE ROLE OF BODY FAT IN LIMITING THE DURATION OF ACTION OF THIOPENTAL

Bernard B. Brodie 1, Eleonore Bernstein 1, and Lester C. Mark 1

1 Section on Chemical Pharmacology, National Heart Institute, National Institutes of Health, Public Health Service, Federal Security Agency, Bethesda, Maryland, and the Research Service, New York University, Goldwater Memorial Hospital, New York, New York

Following the intravenous administration of thiopental to dogs, the anesthetic is rapidly distributed throughout the various organ tissues, including the central nervous system. The concentration of the drug in the various tissues declines rapidly and in a parallel manner.

The concentration of thiopental in fat, at first low, rises rapidly so that the major part of the drug is ultimately localized in the body fat.

It is concluded that thiopental is ultra-short acting after a small dose, not because of its metabolic transformation, which is slow, but because it is rapidly localized in fat.

Submitted on April 4, 1952




This article has been cited by other articles:


Home page
 Drug Metab. Dispos.Home page
M. Weiss, T. C. Krejcie, and M. J. Avram
A Minimal Physiological Model of Thiopental Distribution Kinetics Based on a Multiple Indicator Approach
Drug Metab. Dispos., September 1, 2007; 35(9): 1525 - 1532.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
D. S. Kreuz and J. Axelrod
Delta-9-Tetrahydrocannabinol: Localization in Body Fat
Science, January 26, 1973; 179(4071): 391 - 393.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.