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Journal of Pharmacology And Experimental Therapeutics, Vol. 105, Issue 3, 358-364, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF CORTISONE, DESOXYCORTICOSTERONE, ADRENOCORTICOTROPHIC HORMONE AND DIPHENHYDRAMINE UPON THE RESPONSES OF ALBINO MICE TO GENERAL ANESTHETICS

Charles A. Winter 1 and Lars Flataker 1

1 Merck Institute for Therapeutic Research, Rahway, New Jersey

Cortisone prolongs the induction time and shortens the sleeping time of ether anesthesia in mice under carefully controlled conditions. Desoxycorticosterone has no effect upon induction time, but slightly prolongs the sleeping time. Diphenhydramine has no effect upon induction time, and markedly prolongs the sleeping time. Desoxycorticosterone nullifies the effect of cortisone upon ether anesthesia.

Cortisone or ACTH shortens the sleeping time of barbiturate anesthesia in mice, while desoxycorticosterone is without effect. The markedly prolonged sleeping time of mice receiving both barbiturate and diphenhydramine is also decreased by cortisone, but the effect of the steroid can be fully accounted for by its antagonism to the action of the barbiturate.

In both series of experiments, evidence indicated that cortisone is without effect upon the C.N.S.-depressant effects of the antihistaminic agent.

Submitted on March 17, 1952






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.