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Journal of Pharmacology And Experimental Therapeutics, Vol. 105, Issue 3, 259-264, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE HYDROLYSIS OF PROCAINE AND 2-CHLOROPROCAINE IN SPINAL FLUID

Francis F. Foldes 1 and Manuel H. Aven 1

1 Department of Anesthesia of the Mercy Hospital and the Section on Anesthesiology, Department of Surgery of the University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania

1. The hydrolysis of 2-chloroprocaine in spinal fluid was investigated.

2. Evidence was presented that the hydrolysis of 2-chloroprocaine in spinal fluid is partly alkaline and partly enzymatic.

3. Of the two, the alkaline hydrolysis is predominant.

4. The rate of hydrolysis of 2-chloroprocaine in spinal fluid is more than 100 times slower than in plasma.

Submitted on February 19, 1952






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.