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Journal of Pharmacology And Experimental Therapeutics, Vol. 105, Issue 3, 253-258, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE INHIBITION OF THE HYDROLYSIS OF PROCAINE AND 2-CHLOROPROCAINE IN PLASMA BY NEOSTIGMINE AND DIMETHYLCARBAMATE OF (2-HYDROXY-5-PHENYLBENZYL) TRIMETHYLAMMONIUM BROMIDE (Ro 2-683)

Francis F. Foldes 1 and Manuel H. Aven 1

1 Department of Anesthesia of the Mercy Hospital and the Section on Anesthesiology, Department of Surgery of the University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania

1. The inhibitory effect of neostigmine and Ro 2-683 on procaine esterase was compared using procaine hydrochloride and 2-chloroprocaine hydrochloride as substrates.

2. It was found that both Ro 2-683 and neostigmine are potent inhibitors of procaine esterase. In low concentrations Ro 2-683 was about five times as potent as neostigmine.

3. The inhibitory effect of both neostigmine and Ro 2-683 was due to competitive inhibition.

Submitted on February 19, 1952




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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.