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Journal of Pharmacology And Experimental Therapeutics, Vol. 105, Issue 2, 232-239, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

MYTOLON AND RELATED COMPOUNDS AS ANTAGONISTS OF ACETYLCHOLINE ON THE HEART OF VENUS MERCENARIA

F. P. Luduena 1 and Theodore G. Brown Jr. 1

1 Pharmacology Section, Sterling-Winthrop Research Institute, Rensselaer, New York

1. The acetylcholine (ACh) blocking effect of various ganglionic and neuromuscular blocking agents was determined on the isolated heart of the mollusc, Venus mercenaria.

2. d-Tubocurarine, decamethonium and dihydro-beta-erythroidine showed no acetylcholine (ACh) blocking activity at concentrations as great as 1:10,000. Sparteine has little activity, even at high concentrations (1:10,000).

3. Tetraethylammonium bromide (TEA), and various benzoquinone derivatives reduced and, at higher concentrations, blocked the inhibitory effect of acetylcholine (ACh) on the Venus heart. WIN 2747 [2,5-bis(diethylamino-propylamino)-benzoquinone benzochloride], the most potent compound tested, was about 1000 times more active than tetraethylammonium bromide (TEA).

4. No correlation was found between acetylcholine blocking activity on the Venus heart and ganglionic blocking, curarimimetic or anticholinesterase activities.

Submitted on February 19, 1952




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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.