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Journal of Pharmacology And Experimental Therapeutics, Vol. 105, Issue 2, 203-209, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF ANGELICA LACTONES ON THE TOXICITY OF DIGITOXIN AND ON THE CARDIAC IRREGULARITIES PRODUCED BY DIGITOXIN AND BARIUM

I. T. Beck 1 and J. E. Boulding 1

1 Department of Pharmacology, Faculty of Medicine, McGill University, Montreal (Que.), Canada

The effect of agr-beta and beta-ggr unsaturated angelica lactones upon the cardiac action of digitoxin was studied.

When digitoxin is infused simultaneously with beta-ggr unsaturated angelica lactone, there appears to be no statistically significant change in the toxicity of the glycoside. The rapid superimposed intravenous injection (200 mgm./kgm.) of this lactone during digitoxin infusion in cats induces a premature ventricular fibrillation.

agr-beta Unsaturated angelica lactone does not influence the lethal dose of digitoxin when infused simultaneously with the glycoside. However if 200 mgm./kgm. of the lactone is rapidly injected intravenously it abolishes the digitalis irregularities for a brief period.

The agr-beta lactone also eliminates cardiac irregularities due to barium chloride infusion. Therefore the antagonism of the lactone to digitoxin cannot be explained by the theory of competition of chemically related structures for the same receptors.

Submitted on February 12, 1951






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.