JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow A correction has been published
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brown, R. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brown, R. V.
Journal of Pharmacology And Experimental Therapeutics, Vol. 105, Issue 2, 139-155, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

DOSE-RESPONSE CURVES FOR THE BLOOD PRESSURE EFFECTS PRODUCED BY GRADED DOSES OF L-EPINEPHRINE, A COMMERCIAL EPINEPHRINE, AND L-NOREPINEPHRINE

Robert V. Brown 1

1 Division of Pharmacology, University of Tennessee, Memphis

The data agree well with the postulate that the "true" dose-response curve for the pressor effects of each of the drugs is a rectangular hyperbola. A critical definition of cardiovascular sensitivity, dy/dX, is developed; the concept is tested and appears useful. Two definitions of potency are developed: the absolute potency and the dose (or response) potency. From each a potency ratio which is valid over the entire dosage range can be determined. This ratio requires no assumptions of either equality of dose or of response. It presumes that non-parallelism may be present.

Submitted on January 18, 1952






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.