JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Freyburger, W. A.
Right arrow Articles by Vander Brook, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Freyburger, W. A.
Right arrow Articles by Vander Brook, M. J.
Journal of Pharmacology And Experimental Therapeutics, Vol. 105, Issue 1, 80-86, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE PHARMACOLOGY OF 5-HYDROXYTRYPTAMINE (SEROTONIN)

W. A. Freyburger 1, B. E. Graham 1, M. M. Rapport 1, P. H. Seay 1, W. M. Govier 1, O. F. Swoap 1, and M. J. Vander Brook 2

1 Department of Pharmacology, The Upjohn Company, Kalamazoo, Michigan
2 Department of Pharmacology, The Upjohn Company, Kalamazoo, Michigan, Sloan-Kettering Institute, New York City

1. In the anesthetized cat and dog, serotonin produced somewhat erratic effects on blood pressure.

2. Destruction of the vasomotor center in the dog by pithing through the cervical cord stabilized the blood pressure response to give serotourin about one-fourteenth of the pressor potency of l-epinephrine.

3. Serotonin is less affected by adrenergic blocking agents than are either l-epinephrine or l-norepinephrine.

4. Tachyphylaxis to the pressor effects occurs.

5. In addition to its vascular actions, serotonin has been shown to have constrictor or spasmogenic activity on the isolated bronchial tree, intestine and uterus and the intact intestine and bladder.

6. The agent is rapidly inactivated by amine oxidase.

7. Intravenous toxicity studies give LD50 values of 160 mgm./kgm. in mice and 30 mgm./kgm. in rats.

8. Possible roles of serotonin in the body are discussed.

Submitted on January 28, 1952




This article has been cited by other articles:


Home page
 Reproductive SciencesHome page
Y. Cordeaux, H. Missfelder-Lobos, D. S. Charnock-Jones, and G. C. S. Smith
Stimulation of Contractions in Human Myometrium by Serotonin is Unmasked by Smooth Muscle Relaxants
Reproductive Sciences, September 1, 2008; 15(7): 727 - 734.
[Abstract] [PDF]

Home page
 Arch Intern MedHome page
V. ERSPAMER
OBSERVATIONS ON ALLEGED SEROTONIN- (ENTERAMINE)-LIKE NATURE OF CEREBRAL PRESSOR SUBSTANCE OF TAYLOR, PAGE, AND CORCORAN
Arch Intern Med, October 1, 1952; 90(4): 505 - 512.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.