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Journal of Pharmacology And Experimental Therapeutics, Vol. 105, Issue 1, 74-79, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF BARBITURATE ON THE CARBOHYDRATE METABOLISM OF THE ISOLATED RAT DIAPHRAGM

David E. Haft 1 and I. Arthur Mirsky 1

1 Department of Clinical Science, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

1. The isolated rat diaphragm responds to increasing concentrations of pento-barbital with a marked diminution in respiration, an increased glucose uptake and a decreased glycogen concentration.

2. Increasing concentrations of pentobarbital progressively inhibit the action of insulin on glucose utilization and glycogen content.

3. Under anaerobic conditions, the glucose uptake remains unchanged but the action of insulin is inhibited.

Submitted on January 25, 1952




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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.