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Journal of Pharmacology And Experimental Therapeutics, Vol. 105, Issue 1, 27-36, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF ADRENOCORTICAL STEROIDS AND ADRENOCORTICOTHOPHIC HORMONE ON ELECTROSHOCK SEIZURE THRESHOLD

Dixon M. Woodbury 1

1 Department of Pharmacology, University of Utah College of Medicine, Salt Lake City, Utah

The effect of six adrenocortical steroids on the electroshock seizure threshold (EST) of rats has been tested. DCA and Compound S acetate (11-desoxy-17-hydroxycorticosterone acetate) in a dose of 2 mgm. per day elevated EST DCA was much more potent than Compound S. Compound B acetate (corticosterone acetate), in a dose of 2 mgm. per day, did not significantly alter EST. In doses of 2 mgm. per day, Compound A acetate (11-dehydrocorticosterone acetate) induced a slight decrease, Compound F acetate (17-hydroxycorticosterone acetate) a considerable decrease and cortisone acetate (11-dehydro-17-hydroxycorticosterone acetate) a marked decrease in EST.

ACTH, at dose levels of 0.5, 0.001 and 0.0001 U.S.P. Unit, given in combination with DCA, completely inhibited the elevation of EST observed after DCA alone.

DCA, given in combination with cortisone acetate, inhibited the decrease in EST observed after cortisone acetate alone.

In one experiment, but not in another, ACTH (0.5 U.S.P. Unit per day), given in combination with cortisone, antagonized to a slight extent the decrease in EST observed after cortisone alone. The reason for the discrepancy is discussed.

ACTH (0.5 U.S.P. Unit per day) alone resulted in an increase of 11 per cent in EST after 28 days.

Compound A acetate, given in combination with cortisone acetate, partially prevented the decrease in EST observed after cortisone acetate alone.

Compound S acetate, given in combination with cortisone acetate, did not prevent the decrease in EST observed after cortisone.

The clinical significance of the effects of adrenocortical steroids on brain ex citability is briefly discussed.

Submitted on January 15, 1952




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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.