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Journal of Pharmacology And Experimental Therapeutics, Vol. 105, Issue 1, 101-107, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE PRESSOR EFFECT OF HISTAMINE AFTER AUTOXOMIC GANGLIONIC BLOCKADE

Irwin H. Slater 1 and Peter E. Dresel 1

1 Division of Orthopaedic Surgery, Department of Surgery, and the Division of Pharmacology and Toxicology, Department of Radiation Biology, of the University of Rochester School of Medicine and Dentistry, Rochester, New York

1. After autonomic ganglionic blockade by either tetraethylammonium chloride or hexamethonium bromide, the injection of histamine causes a biphasic alteration in blood pressure, first depressor and then pressor, in cats, but not in dogs.

2. The pressor phase is blocked by Dibenamine and tripelennamine, but is not affected by atropine.

3. Adrenalectomy reduced but did not abolish the pressor phase.

4. Cocaine blocked the pressor response in adrenalectomized cats, but not in intact animals.

5. The significance of these findings as related to the release of epinephrine and/or nor-epinephrine from the adrenals despite blockade of the cholinergic secretory mechanism is discussed.

Submitted on February 8, 1952




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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.