THE CARDIOVASCULAR ACTIONS OF 1-(3-AMINOPHENYL)-2-AMINOETHANOL AND RELATED COMPOUNDS

¹ Pharmacology Section, Sterling-Winthrop Research Institute, Rensselaer, New York

The results obtained in this investigation have shown 1-(3-aminophenyl)-2-aminoethanol and the corresponding -2-methylamino and -2-ethylamino analogs to be effective pressor agents. The primary amine is most pressor and this activity is diminished by alkyl substitution. 1-(3-Aminophenyl)-2-isopropylaminoethanol is depressor. The substitution of the ring with a m-amino group causes a small increase in pressor potency; with a m-hydroxyl group a large increase in pressor potency.

Neither the pressor amine, 1-(3-aminophenyl)-2-aminoethanol, nor its depressor homolog, 1-(3-aminophenyl)-2-isopropylaminoethanol, were effective in preventing bronchoconstriction in guinea pigs exposed to a histamine aerosol.

The acute toxicity (i.p. and i.v. in mice) appears to be less than that of the corresponding unsubstituted and m-hydroxy analogs.