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Journal of Pharmacology And Experimental Therapeutics, Vol. 104, Issue 4, 459-467, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE METABOLISM OF URANIUM233 IN MICE

Walter E. Kisieleski 1, Williams G. Faraghan 1, William P. Norris 1, and James S. Arnold 2

1 Division of Biological and Medical Research, Argonne National Laboratory, Chicago, Illinois
2 College of Medicine, University of Utah, Salt Lake City, Utah

1. A study was made of the retention and distribution of U233 given intravenously to mice at dose levels of 0.05 and 0.005 µc./gm. Animals were sacrificed at intervals of from 30 minutes to 120 days and their body content and tissue concentrations of U233 were determined.

2. Analysis of the data indicates that at both dose levels 60 per cent of the injected dose is retained after 1 day and only 15 per cent remains after 120 days. The U233 is chiefly deposited in bone and kidneys.

3. A number of radioautographs are accompanied with a discussion of the cellular distribution of U233.

Submitted on January 11, 1952






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.