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Journal of Pharmacology And Experimental Therapeutics, Vol. 104, Issue 4, 416-420, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE EFFCTS OF FOUR ANTIHEPARIN DYES ON THE ISOLATED HEARTS OF THE FROG, GUINEA PIG AND RABBIT

James L. Leitch 1 and Thomas J. Haley 1

1 Division of Pharmacology and Toxicology, Atomic Energy Project, University of California at Los Angeles

The pharmacodynamic effects of toluidine blue, azure A, neutral red and neutral violet have been studied on the isolated hearts of the frog, guinea pig and rabbit. These dyes have been shown to produce cholinergic blockade in the frog heart but not in the mammalian heait. The locus of action has been shown to be on the cell surface. The dyes were unable to block the negative inotropic effect of acetylcholine on the mammalian hearts. All of the dyes had a direct cytotoxic effect upon the mammalian hearts and neutral red and neutral violet had a similar effect upon the frog heart. The dyes did not produce adrenergic blockade in any of the heart preparations studied.

Submitted on December 17, 1951






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.