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Journal of Pharmacology And Experimental Therapeutics, Vol. 104, Issue 3, 340-347, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF ALLOXAN, IODOACETATE AND rgr-CHLORO-MERCURIBENZOATE ON CARBOHYDRATE METABOLISM OF THE ISOLATED RAT DIAPHRAGM IN THE ABSENCE AND PRESENCE OF INSULIN

David E. Haft 1 and I. Arthur Mirsky 1

1 Department of Clinical Science, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

1. Exposure of rat diaphragm to alloxan at room temperature for five minutes resulted in a subsequent inhibition of glycogenesis without affecting the utilization of glucose or oxygen.

2. The alloxanized diaphragm responded to insulin with an increase in glucose uptake and glycogenesis. The effectiveness of the insulin diminished with increasing concentrations of alloxan.

3. Glutathione caused a further loss of glycogen by the alloxanized diaphragm instead of reversing the alloxan effect.

4. Anaerobic glycogenolysis was not inhibited by alloxanization.

5. Pretreatment with 0.004 M iodoacetate inhibited glycogenesis without affecting the utilization of glucose or oxygen. Insulin did not augment glycogenesis or the utilization of glucose.

6. Pretreatment with 0.001 M rgr-chloromercuribenzoate resulted in an inhibition of both glycogenesis and respiration. Insulin increased both glucose utilization and glycogenesis. Glutathione produced a partial restoration of glycogenesis.

Submitted on November 26, 1951






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.