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Journal of Pharmacology And Experimental Therapeutics, Vol. 104, Issue 3, 329-333, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

RENAL HEMODYNAMIC AND BLOOD PRESSURE RESPONSE TO N-PHENOXYISOPROPYL-N-BENZYL-beta-CHLORETHYLAMINE (SKF 688A)

John H. Moyer 1 and Carroll A. Handley 1

1 Departments of Medicine and Pharmacology, Baylor University College of Medicine, Houston, Texas

Data on the effect of N-phenoxyisopropyl-N-benzyl-beta-chlorethylamine on renal function were obtained in nine anesthetized and eight unanesthetized dogs. The blood pressure decreased in all but two animals. Glomerular filtration rate and TmG were not altered significantly. Renal vascular resistance decreased in all but the two dogs in which the blood pressure was not depressed. Usually there was a slight increase in renal blood flow. Adrenergic blockade did not increase or decrease the number of functioning nephrons. These observations again suggest autonomous regulation of renal function and indicate that all nephrons were active under the control conditions of the experiment.

Submitted on November 19, 1951






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.