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Journal of Pharmacology And Experimental Therapeutics, Vol. 104, Issue 3, 325-328, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE DETERMINATION OF THE SOLUBILITY OF CYCLOPROPANE IN FATS AND OILS WITH THE USE OF THE WARBURG APPARATUS

Arnold G. Blumberg 1, Bert N. La Du Jr. 1, Gerson T. Lesser 1, and J. Murray Steele 2

1 Research Service, Third (New York University) Medical Division, Goldwater Memorial Hospital, Welfare Island, and the Department of Medicine, New York University College of Medicine, New York, New York
2 Section on Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland

The solubility of cyclopropane in olive oil and in pooled rat fat was determined at various temperatures using the Warburg apparatus.

The results obtained by this method agreed very well with values obtained with a Van Slyke method and in a tonometer system. These values are considerably higher than those previously reported.

The Warburg apparatus can be easily adapted for measuring gas solubility and might be employed to determine the solubility of some of the other highly soluble gases.

Submitted on November 19, 1951






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