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Journal of Pharmacology And Experimental Therapeutics, Vol. 104, Issue 3, 291-298, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

ELECTROENCEPHALOGRAPHIC ANALYSIS OF SIDE EFFECTS OF SPASMOLYTIC DRUGS

William Schallek 1 and Thomas H. F. Smith 1

1 Pharmacology Department, Hoffmann-La Roche Inc., Roche Park, Nutley, New Jersey

This paper describes the effects of five spasmolytic drugs on the electroencephalogram (EEG) of the dog. Simultaneous records were made of the electrocardiogram and the blood pressure.

Atropine was found to increase the EEG frequency at 0.1 mgm./kgm. i.v., and decrease it at 1.0 mgm./kgm.

Syntropan, in doses up to 20 mgm./kgm., had no effect on the EEG.

Ro 2-3202/2 increased the EEG frequency at 0.1 mgm./kgm.; "convulsions" occurred at higher doses.

Ro 2-3308 decreased the EEG frequency at 0.01 mgm./kgm. Higher doses caused bradycardia and ventricular flutter.

Ro 2-3773 in low doses had no effects on the EEG; at 10 mgm./kgm. one out of five dogs showed a decreased frequency.

There is some correlation between the above data and the clinical action of these drugs. It is suggested that this method may be of value in detecting side effects before drugs are sent out for clinical trial.

Submitted on November 8, 1951






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.