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Journal of Pharmacology And Experimental Therapeutics, Vol. 104, Issue 3, 269-276, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

ANTISPASMODIC EFFECTS AND TOXICITY OF N-ETHYL-3-PIPERIDYL-DIPHENYLACETATE HYDROCHLORIDE (JB-305) WITH SPECIAL REFERENCE TO ITS ACTION ON THE SPHINCTER OF ODDI OF THE DOG

James Y. P. Chen 1 and Harry Beckman 2

1 Department of Pharmacology, Schenley Laboratories, Inc., Lawrenceburg, Indiana
2 Department of Pharmacology, Marquette University School of Medicine, Milwaukee, Wisconsin

1. A satisfactory method for recording in situ the actual activity of the sphincter of Oddi of the dog is described.

2. On an equivalent dose basis, 4 mgm./kgm. intravenously, JB-305 (N-ethyl-3-piperidyl-diphenylacetate HCl) appears to be at least as active and no more toxic an antispasmodic agent than Trasentine and papaverine on the sphincter of Oddi, duodenum and apparently also on the ureter.

3. In effective antispasmodic doses, JB-305 is relatively free of any appreciable undesirable side-effects as observed in a total of 46 dogs.

4. Toxicity studies in mice revealed that JB-305 appears definitely no more toxic than Trasentine.

Submitted on October 22, 1951






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