JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kandel, A.
Right arrow Articles by Chenoweth, M. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kandel, A.
Right arrow Articles by Chenoweth, M. B.
Journal of Pharmacology And Experimental Therapeutics, Vol. 104, Issue 2, 234-247, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

METABOLIC DISTURBANCES PRODUCED BY SOME FLUORO-FATTY ACIDS: RELATION TO THE PHARMACOLOGIC ACTIVITY OF THESE COMPOUNDS

Alexander Kandel 1 and Maynard B. Chenoweth 1

1 Department of Pharmacology, University of Michigan, Ann Arbor, Michigan

1. Fluoroacetate, 4-fluorobutyrate and 6-fluorohexanoate cause the accumulation of citrate in the intact animal. 3-Fluoropropionate produces neither citrate nor symptoms of toxicity of fluoro-fatty acid poisoning in rats and dogs.

2. The development of signs and symptoms of fluoroacetate poisoning cannot be ascribed to the citrate which accumulates. The blockade of the tricarboxylic acid cycle, at least as reflected by the accumulation of citrate is, likewise, un-related to the development of symptoms of poisoning.

3. The factors of dosage and duration of poisoning with the fluoro-fatty acids are related to the accumulation of citrate.

4. Glycerol monoacetate (monoacetin) encourages the accumulation of citrate in brain while protecting against fluoroacetate poisoning in rats. It does not protect against 4-fluorobutyrate.

5. Glycerol monobutyrate (monobutyrin) antagonizes 4-fluorobutyrate, but not fluoroacetate, in rats.

Submitted on November 5, 1951






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.